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br Experimental procedures br Conflicts of interests br Intr
2022-06-24
Experimental procedures Conflicts of interests Introduction Here we investigate differences in growth properties and short-term morphological changes in response to ET-1 in Chinese hamster ovary (CHO) cells stably and separately expressing ETA or ETB receptors. A stably transfected CHO syst
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Hypoxia inducible factors HIFs including HIF
2022-06-23
Hypoxia-inducible factors (HIFs), including HIF-1α, HIF-1β, HIF-2α and HIF-3α, are important endogenous signaling proteins that contribute to the cellular response to hypoxia. Among these proteins, HIF-1α is involved in many pathophysiological processes, including inflammation, tumor growth and meta
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HER genotype was determined in
2022-06-23
HER2 genotype was determined in breast cancer tissue of 73 breast cancer patients. As previously reported, Ile655Val and Ala1170Pro genotypes measured in breast cancer tissues were available for 71 and 69 breast cancer patients, respectively. Briefly, 77.5% (55/71) of patients were homozygous for th
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Based on the in vitro findings summarized
2022-06-23
Based on the in vitro findings summarized here, we posited that, in the intact brain, release of ROS from iron-laden astrocytes to the local neuropil elicits oxidative damage and degeneration of indigent dopaminergic projections and other vulnerable neuronal elements (Schipper, 2001). Of particular
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An isoflavone type secondary metabolite Glabrescione B GlaB
2022-06-23
An isoflavone type secondary metabolite, Glabrescione B (GlaB), from Derris glabrescens (Benth.) J.F. Macbr. from the family Fabaceae, was found to possess the capacity to bind the Gli1 zinc finger domain and to further block DNA binding capacity [118]. Pyrvinium, an anthelmintic drug approved by th
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Unlike many interacting proteins NRG was the only one observ
2022-06-23
Unlike many interacting proteins, NRG1 was the only one observed to undergo cleavage by NS3/4A. NRG1 is one of four proteins in the neuregulin family that act on the ErbB member of the EGFR (EGF receptor) family. NRG1 has several isoforms produced by alternative splicing of pro-NRG1, which allows it
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Introduction Epigenetic mechanisms modulate heritable phenot
2022-06-23
Introduction Epigenetic mechanisms modulate heritable phenotypic changes that are not dictated by changes in DNA sequences. The link between epigenetic modifications and cancer development has been established [1], [2]. Histone modifications represent an important class of epigenetic mechanisms tha
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Significan http www apexbt com media diy images
2022-06-23
Significant DNA damage was observed in hemolymph of molluscs exposed to raw composite tannery effluent as evident from comet assay images. DNA damage was evaluated by the presence of tail resembling that of comet in single strand DNA. Break in DNA strand was reported in the liver and gill IL-10, hum
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As a measure of ROS formation we measured the
2022-06-23
As a measure of ROS formation we measured the extent by which Cu(I) affected the production of hydrogen peroxide and, at the same time, to ensure that there would not be shortage of NADH substrate. Our results show that H2O2 production is increased over time by LPS stimulation but it is not when mic
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br Conclusion The wild study reports seasonal variations in
2022-06-23
Conclusion The wild study reports seasonal variations in reproductive physiology, behavior and SB505124 plasticity at different age stages in wild-caught Mongolian gerbils. The gerbils in breeding seasons have more mature sexual development, higher exploratory behavior, higher novelty preference,
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Overall our results indicated the
2022-06-23
Overall, our results indicated the involvement of GABAAR in controlling GnRH/LH release through mechanism which included GABA action on molecular processes leading to GnRH biosynthesis. This is consistent with previous in vivo [14,54] and in vitro [55] studies in ewes suggesting that GABA inhibits G
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LFFs associating with green algae
2022-06-23
LFFs associating with green algae utilize polyols; therefore, we hypothesize that at least one polyol transport system is conserved in LFFs and it is required for the lichenization events that occur widely and independently in Ascomycota. Thus, the present study aimed to first evaluate phylogenetic
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br Transporter based brain targeting nano DDS Drug
2022-06-23
Transporter-based brain-targeting nano-DDS Drug delivery to the central nervous system (CNS) is still challenging due to the bloodbrain barrier (BBB)53., 54.. The BBB is a natural defense barrier protecting the Cefepime Dihydrochloride Monohydrate from harmful substances. Since only selected, ne
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Glutamate is a ubiquitous principal excitatory
2022-06-23
Glutamate is a ubiquitous principal excitatory neurotransmitter in the Piperine synthesis that plays a central role in a variety of brain functions (Delgado, 2013, Hawkins, 2009). Several studies reported that CSF glutamate was associated with mental illness, including major depressive disorder, an
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br Declaration of interest br Acknowledgments This work was
2022-06-23
Declaration of interest Acknowledgments This work was financially supported by the National Natural Science Foundation of China (No. 31471615), the Introduction of Talent Research Start-up Fund of Anhui Polytechnic University (No. 2017YQQ017) and the Pre-research Project of National Natural Sc
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