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br Conclusion B esterases and reproductive parameters can
2021-12-24
Conclusion B-esterases and reproductive parameters can be used as effect biomarkers of the aquatic contamination with chlorpyrifos. In P. corneus exposed for 14 days to the insecticide, the carboxylesterases determined with p-NFB proved to be the most sensitive biomarker. However, exposure to env
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Ikaros utilizes chromatin remodeling to activate or repress
2021-12-24
Ikaros utilizes Ryuvidine remodeling to activate or repress the transcription of its target genes (Su et al., 2004). Ikaros directly associates with histone deacetylases HDAC1 and HDAC2 and can recruit them to the upstream regulatory elements of its target genes (Kim et al., 1999, Koipally et al.,
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Obestatin synthetized mainly in the gastrointestinal
2021-12-24
Obestatin, synthetized mainly in the gastrointestinal tract, participates in the regulation of metabolic functioning at both central and peripheral levels (food intake, pancreatic activity or/and adipocytes proliferation) (Granata et al., 2008; Li et al., 2011). It is involved in the complex gut-bra
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The cytoprotective effects of glyRs have been reported
2021-12-24
The cytoprotective effects of glyRs have been reported to associate with the MAPK (JNK, ERK1/2 and p38) signaling pathways [47], [48]. The present study reveals that suppressive phosphorylation of cRaf-MEK1/2-ERK1/2 is initiated by glycine – glyR α2 interactions in cardiomyocytes. As a central regul
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If some of the experimentally determined tRNAGlu identity el
2021-12-24
If some of the experimentally determined tRNAGlu identity elements are unique to E. coli, then there also must be some unique phylum-specific residues in the corresponding GluRS (E. coli in particular, and proteobacteria in general) as well. In this paper we focus on identifying such residues in E.
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Although in in vitro analyses
2021-12-24
Although in in vitro analyses GANT61 sensitized Daoy PyBOP australia to RITA treatment, this was not fully reflected in the in vivo xenograft studies in nude mice, as the combinatorial treatment elicited a comparable reduction of tumor growth. However, the dual drug administration reduced within-gro
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The NVC response in the diseased or aging brain may
2021-12-24
The NVC response in the diseased or aging HG-9-91-01 may be altered, including changes in both the chemical mediators of NVC, ion channel behaviour, and the dynamics of the vascular system. For example, in Alzheimer’s disease the production of NO is shown to be inhibited (Lourenço et al., 2014), hy
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Recent evidence indicates that prolonged
2021-12-23
Recent evidence indicates that prolonged vasoconstriction of conductance and resistance arteries involves VSMCs Adenine HCl polymerization, through activation of small GTPases [4] and a subsequently transition to a more solid rheology [5]. Actin polymerization occurs in two steps, nucleation and elo
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Following these discoveries the term ferroptosis was
2021-12-23
Following these discoveries, the term ferroptosis was coined in 2012 [25], to describe this iron-dependent, non-apoptotic form cell death induced by erastin and RSL3. This discovery was accompanied by the development of the first small molecule ferroptosis inhibitor, termed ferrostatin-1, and the de
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br Role of catecholamines in HIV associated neuroinflammatio
2021-12-23
Role of catecholamines in HIV-associated neuroinflammation Concluding remarks However, more research is needed to determine the precise mechanisms responsible for the immunomodulatory effects of catecholamines, including the involvement of specific receptors and signaling pathways in immune ce
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The multiple regression analysis showed that
2021-12-23
The multiple regression analysis showed that testing during summer and autumn was associated with higher histamine reactivity, which could be associated with the presence of pollen in the air. Gamboa et al. reported that more histamine was released during spring and autumn than during the other two
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An azabicyclic compound named S a a
2021-12-23
An azabicyclic GSK503 named S 38093, (4-[3-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)propoxy]benzamide), was introduced by Servier with H3R antagonist and inverse agonist activity (Sors et al., 2017). The compound contains all the drug-likeness criteria owing to its physicochemical prope
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br Author contributions br Declaration of conflict of
2021-12-23
Author contributions Declaration of conflict of interest Acknowledgements We are grateful to the Director, National Institute of Immunology for his support. The work was partially supported by J.C. Bose Fellowship to SSM. We acknowledge the help from staff of Small Animal Facility of Nation
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br Disclosures br Introduction The brown planthopper Nilapar
2021-12-23
Disclosures Introduction The brown planthopper, Nilaparvata lugens (Stål) (Hemiptera: Delphacidae), is a classic insecticide-induced resurgent pest throughout Asian rice-growing regions (Chelliah and Heinrichs, 1980). The resurgence of N. lugens induced by commonly used chemical agents has bee
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br Mutagenesis and Receptor Modeling Studies br
2021-12-23
Mutagenesis and Receptor-Modeling Studies Signal Transduction and Receptor Desensitization Therapeutic Potential of HCA Receptor Ligands Although all members of the HCA receptor family are potentially interesting drug targets, only HCA2 is currently exploited as such. Therefore, this sectio
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