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p is a tumor suppressor gene that
2020-10-08
p16 is a tumor-suppressor gene that inhibits cyclin-dependent kinase 4 and 6 activities and arrests the glutamate receptor in the G1 phase. Aberrant methylation and mutation of p16/MTS1 in OSCC of patients was found in our previous study. Moreover, the frequency of hypermethylation of p16 from the p
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br Materials and methods br
2020-10-08
Materials and methods Acknowledgements SD was supported by a pre-doctoral research fellowship from the Flanders Agency for Innovation and Entrepreneurship (VLAIO-Flanders, Belgium). YB is supported by a postdoctoral fellowship from Research Foundation Flanders (FWO, Belgium). We thank Isabelle
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Compounds were prepared via the
2020-10-08
Compounds were prepared via the routes shown in , varying the sequence of reactions to install the thiazole or the phenyl ring at the end of the synthesis (pyridyl examples were prepared using similar chemistry). The aminothiazole building blocks were prepared as shown in . 5-Aminothiazole was prep
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Regarding the mechanism of action of CRF several studies
2020-10-08
Regarding the mechanism of action of CRF, several studies have shown that low doses of CRF may preferentially activate CRF1 receptors in glutamatergic projection neurons, serotoninergic neurons or glutamatergic collaterals in the medial prefrontal cortex (Vertes, 2004). Indeed, prosencephalic inacti
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Allele specific methylation has been observed in CpG
2020-10-08
Allele-specific methylation has been observed in CpG islands of imprinted genes.27, 32 In the present study, however, methylation of CpG1 was specific to ALL MC1568 and occurred in the leukemia cells of 28% of children with ALL, but it was not found in normal leukocytes from the same patients. Meth
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Our approach relied on measurement of bulk solute
2020-10-08
Our approach relied on measurement of bulk solute diffusivity in the three tissue types of interest. Our diffusivity values (Table 3) are on the order of 10−6 cm2/s and are comparable to the PG diffusion coefficient in water at infinite dilution, which is about 10−5 cm2/s at room temperature, as wel
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As shown in Figs a and b with the
2020-10-08
As shown in Figs. 3(a) and (b), with the SO effect, the absolute values of the VDEs change by at most 0.19eV. Table 1 also shows that the observed peak splitting energies in the Sm-Ho complexes were reproduced even without the SO effect. Considering its significant importance in the electronic struc
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The vascular endothelium is a highly dynamic
2020-10-08
The vascular endothelium is a highly dynamic multifunctional organ that is critically involved in the regulation of vessel integrity, vascular growth and remodeling, tissue growth and metabolism, immune responses, cell adhesion, angiogenesis, hemostasis and vascular permeability [23]. Therefore, the
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The results of physical parameters of the
2020-10-08
The results of physical parameters of the prepared samples are summarized in Table 2. The equivalent diameter ranged from 1.09 to 1.14 mm, which is within the required size distribution of 0.8–1.25 mm. A slight increase in size is probably caused by increasing the thickness of the second coat. To d
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a66 receptor A robust meta analysis of randomized
2020-10-06
A robust meta-analysis of 22 randomized clinical trials found that application of ischemic preconditioning strategies reduce ventricular arrhythmias [3]. Additionally, it was demonstrated that remote ischemic perconditioning (perRIC) induces immediate cardioprotection during ongoing ischemia by atte
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This pre GC B cell differentiation deficiency caused by
2020-10-06
This pre-GC B cell differentiation deficiency caused by RD2 loss of function was explained at least in part by the finding that the BCL6 RD2 domain is required to repress expression of the key migration factors GRP183 and S1PR1. Downregulation of GRP183 is critically important for B cell migration i
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Here we report that ILC s sensed oxysterols through GPR
2020-10-06
Here, we report that ILC3s sensed oxysterols through GPR183, which was highly expressed by LTi-like ILC3s. 7α,25-OHC-synthesizing enzymes were produced by fibroblastic stromal UNC 0631 found in intestinal lymphoid structures, and the GPR183 ligand 7α,25-OHC acted as a chemoattractant for ILC3s. GPR
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In most cases patients will not present immediately after SM
2020-10-05
In most cases, patients will not present immediately after SM exposure because SM-induced clinical symptoms typically occur after a latency period of several hours [8], [9], [10]. When they do present, the detection of free, unbound alkylating agent is highly unlikely. For this reason, available rap
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Possibly there are similarities among euphorb plant species
2020-10-05
Possibly there are similarities among euphorb plant species but extraction of the Cy5 azide present in the microsomal fraction is needed for testing their preferences for substrates. Although R. communis, E. lathyris and E. lagascae belong to the same family, the DGAT activity of their microsomal p
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We show that direct contact with MSCs is necessary
2020-10-05
We show that direct contact with MSCs is necessary and sufficient to induce DDR2 upregulation in breast cancer cells. DDR2 expression in MSC is required for collagen deposition and leads to increased DDR2 expression and activation in breast cancer cells. This paracrine-autocrine MSC-cancer cell axis
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