• Aberrant or a sustained activation of AhR signaling pathway

  2024-07-01

  

  Aberrant or a sustained activation of AhR signaling pathway, triggered by exogenous toxic ligands such as dioxins, PAHs or polychlorinated biphenyls (PCBs), is a well-described biological process engaged during tumor initiation and/or promotion in various tissues (e.g. liver, lung, skin)(reviewed in

• Polycyclic aromatic hydrocarbons PAHs are abundant environme

  2024-07-01

  

  Polycyclic aromatic hydrocarbons (PAHs) are abundant environmental contaminants that are produced by the incomplete combustion of organic matter, combustion engines, residential heating, SR 57227 hydrochloride mg burning, and industrial activities (Gelboin, 1980; Phillips, 1999, Phillips, 2002). Som

• The direction of glutamate transport by the cell membrane

  2024-07-01

  

  The direction of glutamate transport by the cell membrane transporter is reversible. As mentioned above, glutamate transport is an electrogenic process associated with a transmembrane ion gradient established by the Na+-K+ pump through hydrolysis of adenosine triphosphate. Under conditions of energy

• Our co IP data show

  2024-07-01

  

  Our co-IP data show that 5HT1A or 5HT2A receptors do not heterodimerize with mGluR1α receptors. Given that both 5-HT and mGlu receptors are GPCRs and produce anxiolytic effects, a degree of cooperativity via a functional cross-talk may still exist between these receptors [11]. In addition to the fun

• Active SI behavior was dose dependently affected by PACAP

  2024-07-01

  

  Active SI behavior was dose-dependently affected by PACAP treatment (F3,25 = 14.42, p 8-CPT-2Me-cAMP, sodium salt 1 week later (F3,20 = 8.93, p PACAP depended on significant dose × day interactions for correct responding (F12,76 = 3.42, p hypothesis that PACAP causes disruptions in posterror adjust

• In this article we have outlined the increasing as yet

  2024-07-01

  

  In this article, we have outlined the increasing, as yet still circumstantial evidence that the 6TM domains of bacterial ACs might operate as receptors for as yet unknown ligands. Intriguingly, several architectural arguments are also applicable to the 6TM domains of mammalian membrane-bound ACs (mA

• hdac inhibitor Our initial approach to identify hits was two

  2024-07-01

  

  Our initial approach to identify hits was two-pronged and included a high-throughput screening (HTS) campaign of the OSI hdac inhibitor library as well as a virtual screening (VS) campaign, utilizing a publically available crystal structure of ACK1 (PDB code: ). A tolerance for protein flexibility

• To date the molecular responses of AChE

  2024-07-01

  

  To date, the molecular responses of AChE have been partially analyzed in its mRNA level or protein activity in aquatic animals. To understand the correlation between transcriptional change and activity of AChE, we conducted both experiments in B. koreanus. Generally, the cçk patterns of the Bk-AChE

• The indirect effect of corporate taxation as given by

  2024-07-01

  

  The indirect effect of corporate taxation, as given by the second term in Eq. (18), consists of two elements; (i) a standard Cy5 TSA Fluorescence System Kit effect (τ/n2), and (ii) a capital cost effect (rG(1−αt)/(1−t)). With a CRS technology, the cost effect vanishes, whereas with an IRS (a DRS) te

• Compounds are representatives of an array of

  2024-07-01

  

  Compounds – are representatives of an array of MBG targets (, ) related to imidazole standard that were synthesized and initially tested in a rat CYP17 lyase screening assay (). The inhibitors were synthesized as racemates by coupling of 6,7-dimethoxy-naphthalene-2-isopropyl ketone with the requisi

• Aurora A or B selective and pan aurora inhibitors

  2024-07-01

  

  Aurora -A or -B selective and pan-aurora inhibitors have demonstrated different preclinical and clinical therapeutic efficacies [2,[19], [20], [21], [22], [23]]. For example, clinical trials for a pan-Aurora inhibitor VX-680 (developed by Vertex) were halted at phase II for toxicity reasons (one cas

• It has been shown that ACLY

  2024-07-01

  

  It has been shown that ACLY is localized to not only the cytoplasm but also the nucleus. Nuclear ACLY may supply acetyl-CoA for histone acetylation, leading to global regulation of the gene expression [16], [18]. We previously reported that AZ2 is also localized to both the cytoplasm and nucleus whe

• Molecular simulation has proven useful in

  2024-07-01

  

  Molecular simulation has proven useful in describing the dynamics and energetics of NMDA receptor LBD cleft closure and the potentiating role of glycans (Yao et al., 2013, Dai and Zhou, 2013, Dai and Zhou, 2015, Dai and Zhou, 2016, Dutta et al., 2015, Omotuyi and Ueda, 2015, Sinitskiy and Pande, 201

• In our study caspase and

  2024-07-01

  

  In our study, caspase3 and DRAM were identified as being involved in full-length AIFM1-induced apoptosis. Caspase3 is best known for its role in the execution phase of apoptosis in both intrinsic and extrinsic apoptotic pathways [17]. The members of the caspase family are generally in inactive pro-f

• br Future view and implications

  2024-06-28

  

  Future view and implications The selection and spread of multi(drug)-resistant microorganisms over the last decades has become a major and global public health concern [35]. Two growing threats originating from the fungal kingdom, i.e. Aspergillus fumigatus and Candida auris[36], [37], re-emphasi

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